Hello Matt!
I discovered, that there is an option in Nvidia Control Panel, that allows to define specific GPU for certain app. So, you can go to Adobe After Effects Support Files folder and duplicate “AfterFX.exe” file to “AfterFX_gpu2.exe” (for example).

After that create shortcuts for both files. Then right-click -> Properties -> Target -> and add ” -m” at the end.

Then open NVIDIA Control Panel, disable SLI Mode, and in “Manage 3D settings” -> “Program Settings” menu add these exe files. For each of them set its own “CUDA – GPUs” and “OpenGL rendering GPU”.



So now you can open 2 copies of After Effects with individual GPU for each of them. Change “Output module” to image sequence, enable Multi-machine “Render Settings” and start render on both AE.
This method might be helpful, when you work with very high resolutions and use a lot of GPU effects, and would like to speed up render time.
I created a short video tutorial about this:
https://www.youtube.com/watch?v=53aVyInhhEo
railwayfx footages
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