Yes, the applications in Master Collection will run on a 64-bit OS.
Here’s a post from the After Effects product maanger about After Effects on Windows 7:
https://blogs.adobe.com/keyframes/2009/10/thinking_windows_7_all_signs_p.html
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Todd Kopriva, Adobe Systems Incorporated
putting the ‘T’ back in ‘RTFM’ : After Effects Help on the Web
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