Hi there,
The default location for Premiere/AME/AE/Encore to store the pek (audio peak), cfa (conformed audio – uncompressed audio from compressed sources), and related intermediate/accelerator files is here:
\Users\\AppData\Roaming\Adobe\Common\Media Cache and Media Cache Files
So long as none of the said applications are running, you can freely delete these two directories, and they’ll be recreated on next launch. However, since this is where these accelerator files are shared, they’ll be recreated next time you import a source that needs one.
For example, in Premiere you can change where these files are stored by going to Edit > Preferences > Media, and change the Media Cache Files for example. Media Cache stores .mcdb files which is the relationship between the media and the accelerator.
Cheers,
-EricS