The admittedly confusing language about After Effects CS4 being “optimized for 64-bit” was referring to the fact that After Effects CS4 could start multiple instances of itself to take advantage of all of the memory in your system. Each of those instances, being a 32-bit application, could only use 4GB of RAM.
With After Effects CS5 and later, each instance of After Effects can use any amount of RAM that you have installed.
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Todd Kopriva, Adobe Systems Incorporated
Technical Support for professional video software
After Effects Help & Support
Premiere Pro Help & Support
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