There is a difference when you look at the raw video but the answer to your question depends on several factors such as 1. How much will you be color grading or adjusting the image in post? 2. How are you exporting your finished project? 3. Export settings? 4. Is it for web? Blu-Ray? DVD? Broadcast? The biggest of these is how much will you change the image in post? The 4:2:2 50Mbs will give you more flexibility in manipulating the image after the fact. However, once both raw images are put through post and then exported out the compression usually leaves a final image quality to a point where you can’t tell a difference between the two. I have the NX5 and I’m assuming the other cam you are considering is the PMW200. The most importance difference with the 200 is the 1/2″ chip versus the NX5 1/3″ chips and that is definitely worth the extra money.